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Regioselective o ‐Hydroxylation of Monosubstituted Benzenes by P450 BM3
Author(s) -
Dennig Alexander,
Lülsdorf Nina,
Liu Haifeng,
Schwaneberg Ulrich
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303986
Subject(s) - hydroxylation , regioselectivity , anisole , chemistry , toluene , monooxygenase , catalysis , medicinal chemistry , organic chemistry , cytochrome p450 , enzyme
Dream come true : A new monooxygenase catalyst shows excellent activity for the hydroxylation of halogenated benzenes, anisole, and toluene with almost complete ortho regioselectivity (see scheme; R=F, Cl, Br, I, CH 3 , OCH 3 ). The substrates were hydroxylated at room temperature in water without cosolvent using molecular oxygen as oxidant.