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Asymmetric Catalytic 1,6‐Conjugate Addition/Aromatization of para ‐Quinone Methides: Enantioselective Introduction of Functionalized Diarylmethine Stereogenic Centers
Author(s) -
Chu WenDao,
Zhang LeFen,
Bao Xu,
Zhao XianHe,
Zeng Chao,
Du JiYuan,
Zhang GuoBiao,
Wang FangXin,
Ma XiaoYan,
Fan ChunAn
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303928
Subject(s) - enantioselective synthesis , stereocenter , conjugate , aromatization , quinone , computer science , catalysis , chemistry , combinatorial chemistry , world wide web , organic chemistry , mathematics , mathematical analysis
It′s just a phase : The title reaction sequence of para ‐quinone methides ( p ‐QMs) has been developed with malonates under phase‐transfer catalysis. The reaction also offers an alternative route to asymmetric construction of diarylmethine stereocenters in excellent enantioselectivities and high yields.