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Palladium/Copper‐Catalyzed Oxidative CH Alkenylation/N‐Dealkylative Carbonylation of Tertiary Anilines
Author(s) -
Shi Renyi,
Lu Lijun,
Zhang Hua,
Chen Borui,
Sha Yuchen,
Liu Chao,
Lei Aiwen
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303911
Subject(s) - carbonylation , palladium , catalysis , chemistry , oxidative phosphorylation , copper , organic chemistry , polymer chemistry , medicinal chemistry , combinatorial chemistry , carbon monoxide , biochemistry
CH/CN activation : The first palladium/copper‐catalyzed aerobic oxidative CH alkenylation/ N ‐dealkylative carbonylation of tertiary anilines has been developed. Various functional groups were tolerated and acrylic ester could also be suitable substrates. This transformation provided efficient and straightforward synthesis of biologically active 3‐methyleneindolin‐2‐one derivatives from cheap and simple substrates.