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Convergent Chemical Synthesis of Histone H2B Protein for the Site‐Specific Ubiquitination at Lys34
Author(s) -
Siman Peter,
Karthikeyan Subramanian Vedhanarayanan,
Nikolov Miroslav,
Fischle Wolfgang,
Brik Ashraf
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303844
Subject(s) - histone h2b , ubiquitin , histone , posttranslational modification , chemistry , microbiology and biotechnology , convergent synthesis , chemical synthesis , biochemistry , biology , stereochemistry , enzyme , dna , in vitro , gene
As You Like It : The convergent chemical synthesis of the histone H2B protein was achieved. This approach enabled the attachment of ubiquitin at Lys34 (see picture) and should make it possible to synthesize H2B with any other posttranslational modification in demand.