Premium
Enantioselective CH Arylation Strategy for Functionalized Dibenzazepinones with Quaternary Stereocenters
Author(s) -
Saget Tanguy,
Cramer Nicolai
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303816
Subject(s) - enantioselective synthesis , stereocenter , phosphoramidite , regioselectivity , combinatorial chemistry , palladium , amide , catalysis , chemistry , computer science , organic chemistry , dna , biochemistry , oligonucleotide
Tada ! Highly functionalized chiral dibenzazepinones are obtained by a mild palladium(0)‐catalyzed enantioselective CH arylation with excellent selectivities by using simple taddol phosphoramidite ligands. The amide tether allows exclusive regioselectivity through a rare eight‐membered palladacycle intermediate.