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Copper‐Catalyzed Intramolecular Electrophilic Carbofunctionalization of Allylic Amides
Author(s) -
Cahard Elise,
Bremeyer Nadine,
Gaunt Matthew J.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303724
Subject(s) - allylic rearrangement , intramolecular force , electrophile , chemistry , catalysis , aryl , ring (chemistry) , combinatorial chemistry , copper , organic chemistry , computer science , alkyl
An endo ‐selective copper‐catalyzed oxyarylation and oxyvinylation of allylic amides was developed. The products are the six‐membered ring oxazines and are formed exclusively as the anti isomers. A range of substituted allylic amides and a wide selection of diaryliodonium and vinyl(aryl)iodonium triflates are compatible with this transformation.
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