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The Ferroquine Antimalarial Conundrum: Redox Activation and Reinvasion Inhibition
Author(s) -
Dubar Faustine,
Slomianny Christian,
Khalife Jamal,
Dive Daniel,
Kalamou Hadidjatou,
Guérardel Yann,
Grellier Philippe,
Biot Christophe
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303690
Subject(s) - chloroquine , oxidizing agent , plasmodium falciparum , quinoline , vacuole , chemistry , malaria , mechanism of action , redox , quinine , neuraminidase , biochemistry , pharmacology , biology , in vitro , enzyme , immunology , organic chemistry , cytoplasm
Metal health : Ferroquine is a ferrocene‐based analogue of the antimalarial drug chloroquine. In addition to the primary mechanism of quinoline action, fluorescent probe studies in infected red blood cells show another mechanism is at work. It is based on the production of HO . in the acidic and oxidizing environment of the digestive vacuole of the malaria parasite and implies that, with ferroquine, reinvasion can be inhibited.