Rh/Pd Catalysis with Chiral and Achiral Ligands: Domino Synthesis of Aza‐Dihydrodibenzoxepines | Zendy

Friedman Adam A. | Zendy; Panteleev Jane | Zendy; Tsoung Jennifer | Zendy; Huynh Vaizanne | Zendy; Lautens Mark | Zendy

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Rh/Pd Catalysis with Chiral and Achiral Ligands: Domino Synthesis of Aza‐Dihydrodibenzoxepines

Author(s) -

Friedman Adam A.,

Panteleev Jane,

Tsoung Jennifer,

Huynh Vaizanne,

Lautens Mark

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201303659

Subject(s) - domino , catalysis , ligand (biochemistry) , combinatorial chemistry , chemistry , enantioselective synthesis , transformation (genetics) , component (thermodynamics) , metal , stereochemistry , organic chemistry , physics , receptor , biochemistry , thermodynamics , gene

A game of dominoes : A synthetic route to aza‐dihydrodibenzoxepines is described, through the combination of a Rh‐catalyzed arylation and a Pd‐catalyzed C‐O coupling in a single pot. For the first time, the ability to incorporate a chiral and an achiral ligand in a two‐component, two‐metal transformation is achieved, giving the products in moderate to good yields, with excellent enantioselectivities.

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