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Rh/Pd Catalysis with Chiral and Achiral Ligands: Domino Synthesis of Aza‐Dihydrodibenzoxepines
Author(s) -
Friedman Adam A.,
Panteleev Jane,
Tsoung Jennifer,
Huynh Vaizanne,
Lautens Mark
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303659
Subject(s) - domino , catalysis , ligand (biochemistry) , combinatorial chemistry , chemistry , enantioselective synthesis , transformation (genetics) , component (thermodynamics) , metal , stereochemistry , organic chemistry , physics , receptor , biochemistry , thermodynamics , gene
A game of dominoes : A synthetic route to aza‐dihydrodibenzoxepines is described, through the combination of a Rh‐catalyzed arylation and a Pd‐catalyzed C‐O coupling in a single pot. For the first time, the ability to incorporate a chiral and an achiral ligand in a two‐component, two‐metal transformation is achieved, giving the products in moderate to good yields, with excellent enantioselectivities.