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Inside Cover: Rational Design of an Apoptosis‐Inducing Photoreactive DNA Intercalator (Angew. Chem. Int. Ed. 24/2013)
Author(s) -
Ueberschaar Nico,
Dahse HansMartin,
Bretschneider Tom,
Hertweck Christian
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303645
Subject(s) - intercalation (chemistry) , apoptosis , dna , int , cover (algebra) , chemistry , rational design , colorectal cancer , cancer research , biophysics , microbiology and biotechnology , stereochemistry , cancer , biochemistry , nanotechnology , materials science , biology , organic chemistry , genetics , computer science , mechanical engineering , engineering , operating system
Vinylchartreusin , a chartreusin analogue that intercalates in double‐stranded DNA, was prepared by mutasynthesis to design a photoactivatable antitumoral agent that is able to form [2+2] photoadducts. In their Communication on page 6185 ff., C. Hertweck and co‐workers report substantially higher antiproliferative activities of this compound compared with the natural product upon irradiation with visible light. Colorectal cancer cells (see background) show signs of apoptosis after treatment with vinylchartreusin and blue light.