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Chiral Scandium(III)‐Catalyzed Enantioselective α‐Arylation of N‐Unprotected 3‐Substituted Oxindoles with Diaryliodonium Salts
Author(s) -
Guo Jing,
Dong Shunxi,
Zhang Yulong,
Kuang Yulong,
Liu Xiaohua,
Lin Lili,
Feng Xiaoming
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303602
Subject(s) - scandium , enantioselective synthesis , catalysis , electrophile , aryl , reactivity (psychology) , chemistry , combinatorial chemistry , carbon fibers , lewis acids and bases , organic chemistry , computer science , alkyl , medicine , alternative medicine , pathology , algorithm , composite number
Catalytic asymmetric α‐arylation of N‐unprotected 3‐substituted oxindoles with diaryliodonium salts has been realized by a chiral Lewis acid promoted electrophilic addition and aryl‐rearrangement process. Single C3‐arylated products containing a quaternary carbon center were generated in high enantioselectivity and reactivity.