Regioselective Wacker Oxidation of Internal Alkenes: Rapid Access to Functionalized Ketones Facilitated by Cross‐Metathesis | Zendy

Morandi Bill | Zendy; Wickens Zachary K. | Zendy; Grubbs Robert H. | Zendy

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Regioselective Wacker Oxidation of Internal Alkenes: Rapid Access to Functionalized Ketones Facilitated by Cross‐Metathesis

Author(s) -

Morandi Bill,

Wickens Zachary K.,

Grubbs Robert H.

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201303587

Subject(s) - regioselectivity , wacker process , metathesis , chemistry , combinatorial chemistry , benzoquinone , alkene , salt metathesis reaction , organic chemistry , catalysis , palladium , polymerization , polymer

Wacka wacka : The title reaction makes use of a wide range of directing groups (DG) to enable the highly regioselective oxidation of alkenes, and occurs predictably at the distal position. Both E and Z alkenes afford valuable functionalized ketones and cross‐metathesis was shown to facilitate the preparation of the starting materials. BQ=benzoquinone.

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