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Oxidative Trifluoromethylation of Unactivated Olefins: An Efficient and Practical Synthesis of α‐Trifluoromethyl‐Substituted Ketones
Author(s) -
Deb Arghya,
Manna Srimanta,
Modak Atanu,
Patra Tuhin,
Maity Soham,
Maiti Debabrata
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303576
Subject(s) - trifluoromethylation , trifluoromethyl , variety (cybernetics) , chemistry , reagent , simple (philosophy) , broad spectrum , organic chemistry , service (business) , combinatorial chemistry , computer science , business , philosophy , alkyl , epistemology , marketing , artificial intelligence
An economical approach to α‐CF 3 ‐substituted ketones, which are important intermediates in synthetic and medicinal chemistry, employs olefins and the readily available Langlois reagent (CF 3 SO 2 Na). The reaction is operationally simple, proceeds at room temperature, and exhibits an excellent tolerance toward a wide variety of functional groups.