Oxidative Trifluoromethylation of Unactivated Olefins: An Efficient and Practical Synthesis of α‐Trifluoromethyl‐Substituted Ketones | Zendy

Deb Arghya | Zendy; Manna Srimanta | Zendy; Modak Atanu | Zendy; Patra Tuhin | Zendy; Maity Soham | Zendy; Maiti Debabrata | Zendy

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Oxidative Trifluoromethylation of Unactivated Olefins: An Efficient and Practical Synthesis of α‐Trifluoromethyl‐Substituted Ketones

Author(s) -

Deb Arghya,

Manna Srimanta,

Modak Atanu,

Patra Tuhin,

Maity Soham,

Maiti Debabrata

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201303576

Subject(s) - trifluoromethylation , trifluoromethyl , variety (cybernetics) , chemistry , reagent , simple (philosophy) , broad spectrum , organic chemistry , service (business) , combinatorial chemistry , computer science , business , philosophy , alkyl , epistemology , marketing , artificial intelligence

An economical approach to α‐CF 3 ‐substituted ketones, which are important intermediates in synthetic and medicinal chemistry, employs olefins and the readily available Langlois reagent (CF 3 SO 2 Na). The reaction is operationally simple, proceeds at room temperature, and exhibits an excellent tolerance toward a wide variety of functional groups.

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