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Enantioselective Cyanoethoxycarbonylation of Isatins Promoted by a Lewis Base–Brønsted Acid Cooperative Catalyst
Author(s) -
Ogura Yoshihiro,
Akakura Matsujiro,
Sakakura Akira,
Ishihara Kazuaki
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303572
Subject(s) - enantioselective synthesis , catalysis , computer science , chemistry , lewis acids and bases , brønsted–lowry acid–base theory , base (topology) , combinatorial chemistry , world wide web , organic chemistry , mathematics , mathematical analysis
Teaming up to make it happen : In the title reaction, the Lewis basic site of the catalyst activated ethyl cyanoformate, and the deep and flexible Brønsted acidic cavity stabilized and selectively recognized the key reaction intermediate to promote asymmetric acylation (see scheme).