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Nanopore‐Based Sequencing and Detection of Nucleic Acids
Author(s) -
Ying YiLun,
Zhang Junji,
Gao Rui,
Long YiTao
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303529
Subject(s) - nanopore , nucleic acid , nucleic acid quantitation , nanopore sequencing , nanotechnology , solid state , computational biology , computer science , chemistry , dna sequencing , biology , dna , materials science , biochemistry
Nanopore‐based techniques, which mimic the functions of natural ion channels, have attracted increasing attention as unique methods for single‐molecule detection. The technology allows the real‐time, selective, high‐throughput analysis of nucleic acids through both biological and solid‐state nanopores. In this Minireview, the background and latest progress in nanopore‐based sequencing and detection of nucleic acids are summarized, and light is shed on a novel platform for nanopore‐based detection.