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Full Functionalization of the 7‐Azaindole Scaffold by Selective Metalation and Sulfoxide/Magnesium Exchange
Author(s) -
Barl Nadja M.,
SansiaumeDagousset Elodie,
Karaghiosoff Konstantin,
Knochel Paul
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303490
Subject(s) - metalation , magnesium , surface modification , sulfoxide , chemistry , combinatorial chemistry , information exchange , service (business) , halogen , computer science , organic chemistry , business , telecommunications , alkyl , marketing
Filling positions : 7‐Azaindoles are important targets in the pharmaceutical industry. All five carbon positions of the azaindole ring system can be functionalized in a predictable manner starting from the appropriately substituted azaindole 1 by directed metalation and halogen/magnesium and sulfoxide/magnesium exchange. The products are fully substituted azaindoles of type 2 .