Full Functionalization of the 7‐Azaindole Scaffold by Selective Metalation and Sulfoxide/Magnesium Exchange | Zendy

Barl Nadja M. | Zendy; SansiaumeDagousset Elodie | Zendy; Karaghiosoff Konstantin | Zendy; Knochel Paul | Zendy

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Full Functionalization of the 7‐Azaindole Scaffold by Selective Metalation and Sulfoxide/Magnesium Exchange

Author(s) -

Barl Nadja M.,

SansiaumeDagousset Elodie,

Karaghiosoff Konstantin,

Knochel Paul

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201303490

Subject(s) - metalation , magnesium , surface modification , sulfoxide , chemistry , combinatorial chemistry , information exchange , service (business) , halogen , computer science , organic chemistry , business , telecommunications , alkyl , marketing

Filling positions : 7‐Azaindoles are important targets in the pharmaceutical industry. All five carbon positions of the azaindole ring system can be functionalized in a predictable manner starting from the appropriately substituted azaindole 1 by directed metalation and halogen/magnesium and sulfoxide/magnesium exchange. The products are fully substituted azaindoles of type 2 .

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