Premium
Inside View of a Giant Proton Pump
Author(s) -
Brandt Ulrich
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303403
Subject(s) - bioenergetics , proton , resolution (logic) , chemiosmosis , coupling (piping) , electrochemical gradient , chemical physics , redox , chemistry , atp synthase , biophysics , membrane , physics , biology , materials science , enzyme , biochemistry , computer science , nuclear physics , artificial intelligence , inorganic chemistry , mitochondrion , metallurgy
Inner workings : The X‐ray crystal structure of the entire bacterial complex I at 3.3 Å resolution offers fascinating insights into a giant 536 kDa molecular machine. The respiratory chain complex seems to employ unique mechanisms of energetic coupling that are entirely different from those found in all other enzymes using redox energy to drive vectorial proton transport across a bioenergetic membrane.