Premium
Selective C sp 2 C sp Bond Cleavage: The Nitrogenation of Alkynes to Amides
Author(s) -
Qin Chong,
Feng Peng,
Ou Yang,
Shen Tao,
Wang Teng,
Jiao Ning
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303376
Subject(s) - surface modification , cleavage (geology) , bond cleavage , aryl , chemistry , substrate (aquarium) , combinatorial chemistry , catalysis , medicinal chemistry , stereochemistry , organic chemistry , materials science , biology , alkyl , fracture (geology) , composite material , ecology
Breakthrough : A novel catalyzed direct highly selective C sp 2C sp bond functionalization of alkynes to amides has been developed. Nitrogenation is achieved by the highly selective C sp 2C sp bond cleavage of aryl‐substituted alkynes. The oxidant‐free and mild conditions and wide substrate scope make this method very practical.