Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid‐Anchored Peptide Vaccines | Zendy

Koers Eline J. | Zendy; LópezDeber Maria Pilar | Zendy; Weingarth Markus | Zendy; Nand Deepak | Zendy; Hickman David T. | Zendy; Mlaki Ndao Dorin | Zendy; Reis Pedro | Zendy; Granet Anne | Zendy; Pfeifer Andrea | Zendy; Muhs Andreas | Zendy; Baldus Marc | Zendy

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Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid‐Anchored Peptide Vaccines

Author(s) -

Koers Eline J.,

LópezDeber Maria Pilar,

Weingarth Markus,

Nand Deepak,

Hickman David T.,

Mlaki Ndao Dorin,

Reis Pedro,

Granet Anne,

Pfeifer Andrea,

Muhs Andreas,

Baldus Marc

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201303374

Subject(s) - liposome , nuclear magnetic resonance spectroscopy , peptide , spectroscopy , random coil , polarization (electrochemistry) , chemistry , multitude , nanotechnology , computer science , computational biology , materials science , physics , biochemistry , biology , stereochemistry , protein secondary structure , political science , quantum mechanics , law

Sensitivity is the key : Dynamic nuclear polarization NMR spectroscopy provides structural information on liposomal vaccines targeting Alzheimer's disease. DMPC/DMPG/Cholesterol mainly stabilizes extended structures of the lipid‐anchored peptide, while in DMTAP/Cholesterol liposomes the peptide adopts a multitude of conformations including random‐coil and extended structures.

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