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Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid‐Anchored Peptide Vaccines
Author(s) -
Koers Eline J.,
LópezDeber Maria Pilar,
Weingarth Markus,
Nand Deepak,
Hickman David T.,
Mlaki Ndao Dorin,
Reis Pedro,
Granet Anne,
Pfeifer Andrea,
Muhs Andreas,
Baldus Marc
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303374
Subject(s) - liposome , nuclear magnetic resonance spectroscopy , peptide , spectroscopy , random coil , polarization (electrochemistry) , chemistry , multitude , nanotechnology , computer science , computational biology , materials science , physics , biochemistry , biology , stereochemistry , protein secondary structure , political science , quantum mechanics , law
Sensitivity is the key : Dynamic nuclear polarization NMR spectroscopy provides structural information on liposomal vaccines targeting Alzheimer's disease. DMPC/DMPG/Cholesterol mainly stabilizes extended structures of the lipid‐anchored peptide, while in DMTAP/Cholesterol liposomes the peptide adopts a multitude of conformations including random‐coil and extended structures.