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Trifluoromethylation Reactions for the Synthesis of β‐Trifluoromethylamines
Author(s) -
Egami Hiromichi,
Kawamura Shintaro,
Miyazaki Ayako,
Sodeoka Mikiko
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303350
Subject(s) - trifluoromethylation , reagent , chemistry , component (thermodynamics) , combinatorial chemistry , scheme (mathematics) , variety (cybernetics) , organic chemistry , computer science , mathematics , trifluoromethyl , physics , mathematical analysis , alkyl , artificial intelligence , thermodynamics
A multitalented system : N ‐Migratory oxytrifluoromethylation and one‐pot three‐component reactions of allylamines as well as the aminotrifluoromethylation of alkenyl amines all proceeded efficiently in the presence of the Togni reagent ( 1 ) and CuI to afford a variety of β‐trifluoromethylamine derivatives (see scheme).