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Light‐Regulated Stapled Peptides to Inhibit Protein–Protein Interactions Involved in Clathrin‐Mediated Endocytosis
Author(s) -
Nevola Laura,
MartínQuirós Andrés,
Eckelt Kay,
Camarero Núria,
Tosi Sébastien,
Llobet Artur,
Giralt Ernest,
Gorostiza Pau
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303324
Subject(s) - endocytosis , internalization , receptor mediated endocytosis , clathrin , microbiology and biotechnology , biology , cell , computational biology , biochemistry
Control of membrane traffic : Photoswitchable inhibitors of protein–protein interactions were applied to photoregulate clathrin‐mediated endocytosis (CME) in living cells. Traffic light (TL) peptides acting as “stop” and “go” signals for membrane traffic can be used to dissect the role of CME in receptor internalization and in cell growth, division, and differentiation.