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Addressing Challenges in Palladium‐Catalyzed Cross‐Couplings of Aryl Mesylates: Monoarylation of Ketones and Primary Alkyl Amines
Author(s) -
Alsabeh Pamela G.,
Stradiotto Mark
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303305
Subject(s) - aryl , methylamine , primary (astronomy) , amine gas treating , alkyl , ketone , chemistry , catalysis , combinatorial chemistry , palladium , organic chemistry , computer science , database , physics , astronomy
Mor(DalPhos) for Me(sylates) : Described are the first examples of ketone mono‐α‐arylation and primary aliphatic amine monoarylation employing aryl methanesulfonate coupling partners. A range of functionalized aryl mesylates were employed with dialkyl ketones, and also with primary and secondary amines as well as the otherwise challenging coupling partners acetone and methylamine. Ad=adamantyl.