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Cover Picture: A Facile Strategy for Selective Incorporation of Phosphoserine into Histones (Angew. Chem. Int. Ed. 22/2013)
Author(s) -
Lee Sangsik,
Oh Seunghee,
Yang Aerin,
Kim Jihyo,
Söll Dieter,
Lee Daeyoup,
Park HeeSung
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303269
Subject(s) - phosphoserine , serine , histone , phosphorylation , biochemistry , histone h3 , chemistry , biology , dna
Selective phosphoserine incorporation is described by H.‐S. Park et al. in their Communication on page 5771 ff. A general strategy for producing recombinant histones with site‐specific serine phosphorylation has been developed by engineering phosphoseryl‐tRNA synthethase (SepRS) and elongation factor Tu (EF‐Tu). This method should facilitate the study of histone phosphorylation and cross‐regulatory mechanisms.