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Robust Structure and Reactivity of Aqueous Arsenous Acid–Platinum(II) Anticancer Complexes
Author(s) -
Miodragović Ðenana U.,
Quentzel Jeremy A.,
Kurutz Josh W.,
Stern Charlotte L.,
Ahn Richard W.,
Kandela Irawati,
Mazar Andrew,
O'Halloran Thomas V.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303251
Subject(s) - chemistry , library science , computer science
Anticancer drugs based on molecular adducts of platinum and arsenic (arsenoplatins) show an unanticipated structure, substitution chemistry, and cellular cytotoxicity. The Pt II –As III bonds in these complexes are stable in aqueous solution and strongly influence the lability of the trans ligand.