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Mycalol: A Natural Lipid with Promising Cytotoxic Properties against Human Anaplastic Thyroid Carcinoma Cells
Author(s) -
Cutignano Adele,
Nuzzo Genoveffa,
D'Angelo Daniela,
Borbone Eleonora,
Fusco Alfredo,
Fontana Angelo
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303039
Subject(s) - cytotoxicity , cytotoxic t cell , cancer research , tumor cells , cell culture , thyroid , carcinoma cell , biology , chemistry , biochemistry , in vitro , endocrinology , genetics
From Antarctic waters : Human anaplastic thyroid carcinoma (ATC) cells which stably express antisense construct against nuclear high‐mobility group A (HMGA) proteins were used in a novel phenotypic assay for screening marine natural extracts. The rational search led to the isolation and identification of a novel polyoxygenated linear lipid ( 1 ) that showed important and selective cytotoxicity against ATC‐derived tumor cell lines.