Mycalol: A Natural Lipid with Promising Cytotoxic Properties against Human Anaplastic Thyroid Carcinoma Cells | Zendy

Cutignano Adele | Zendy; Nuzzo Genoveffa | Zendy; D'Angelo Daniela | Zendy; Borbone Eleonora | Zendy; Fusco Alfredo | Zendy; Fontana Angelo | Zendy

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Mycalol: A Natural Lipid with Promising Cytotoxic Properties against Human Anaplastic Thyroid Carcinoma Cells

Author(s) -

Cutignano Adele,

Nuzzo Genoveffa,

D'Angelo Daniela,

Borbone Eleonora,

Fusco Alfredo,

Fontana Angelo

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201303039

Subject(s) - cytotoxicity , cytotoxic t cell , cancer research , tumor cells , cell culture , thyroid , carcinoma cell , biology , chemistry , biochemistry , in vitro , endocrinology , genetics

From Antarctic waters : Human anaplastic thyroid carcinoma (ATC) cells which stably express antisense construct against nuclear high‐mobility group A (HMGA) proteins were used in a novel phenotypic assay for screening marine natural extracts. The rational search led to the isolation and identification of a novel polyoxygenated linear lipid ( 1 ) that showed important and selective cytotoxicity against ATC‐derived tumor cell lines.

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