Premium
Catalytic Asymmetric Hydrogenation of δ‐Ketoesters: Highly Efficient Approach to Chiral 1,5‐Diols
Author(s) -
Yang XiaoHui,
Xie JianHua,
Liu WeiPeng,
Zhou QiLin
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303011
Subject(s) - catalysis , enantioselective synthesis , asymmetric hydrogenation , chemistry , combinatorial chemistry , noyori asymmetric hydrogenation , organic chemistry
High turnover : An highly efficient catalytic asymmetric hydrogenation of δ‐aryl‐δ‐ketoesters has been realized by using the chiral spiroiridium catalyst ( R )‐ 1 . Chiral 1,5‐diol products are obtained with excellent enantioselectivity and turnover numbers (TONs) as high as 100 000. TOF=turnover frequency.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom