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Selective Reduction of Esters to Aldehydes under the Catalysis of Well‐Defined NHC–Iron Complexes
Author(s) -
Li Haoquan,
Misal Castro Luis C.,
Zheng Jianxia,
Roisnel Thierry,
Dorcet Vincent,
Sortais JeanBaptiste,
Darcel Christophe
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201303003
Subject(s) - hydrosilylation , chemistry , chemoselectivity , hydride , catalysis , carbene , reactivity (psychology) , organic chemistry , reagent , aldehyde , combinatorial chemistry , metal , medicine , alternative medicine , pathology
On a direct course to the aldehyde : Hydrosilylation catalyzed by a well‐defined N‐heterocyclic‐carbene–iron complex under UV irradiation enabled the selective reduction of esters to aldehydes (see scheme; Bn=benzyl, Mes=mesityl). The low catalyst loading and very mild reaction conditions make this chemoselective transformation a promising alternative to the reduction of esters with diisobutylaluminum hydride.