α‐Boryl Isocyanides Enable Facile Preparation of Bioactive Boropeptides | Zendy

Zajdlik Adam | Zendy; Wang Zezhou | Zendy; Hickey Jennifer L. | Zendy; Aman Ahmed | Zendy; Schimmer Aaron D. | Zendy; Yudin Andrei K. | Zendy

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α‐Boryl Isocyanides Enable Facile Preparation of Bioactive Boropeptides

Author(s) -

Zajdlik Adam,

Wang Zezhou,

Hickey Jennifer L.,

Aman Ahmed,

Schimmer Aaron D.,

Yudin Andrei K.

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201302818

Subject(s) - computer science , service (business) , world wide web , content delivery , chemistry , combinatorial chemistry , information retrieval , business , computer network , marketing

Entry to bioactive boropeptides : MIDA‐containing α‐boryl isocyanides are isolable molecules which allow one‐step access to boroalkyl‐functionalized heterocycles as well as biologically active boropeptides through a multicomponent approach. Among these derivatives are 6‐boromorpholinones, novel borocycles with nanomolar IC 50 values for 20S proteasome inhibition. MIDA= N ‐methyliminodiacetyl.

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