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α‐Boryl Isocyanides Enable Facile Preparation of Bioactive Boropeptides
Author(s) -
Zajdlik Adam,
Wang Zezhou,
Hickey Jennifer L.,
Aman Ahmed,
Schimmer Aaron D.,
Yudin Andrei K.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302818
Subject(s) - computer science , service (business) , world wide web , content delivery , chemistry , combinatorial chemistry , information retrieval , business , computer network , marketing
Entry to bioactive boropeptides : MIDA‐containing α‐boryl isocyanides are isolable molecules which allow one‐step access to boroalkyl‐functionalized heterocycles as well as biologically active boropeptides through a multicomponent approach. Among these derivatives are 6‐boromorpholinones, novel borocycles with nanomolar IC 50 values for 20S proteasome inhibition. MIDA= N ‐methyliminodiacetyl.