Nickel‐Mediated Radioiodination of Aryl and Heteroaryl Bromides: Rapid Synthesis of Tracers for SPECT Imaging | Zendy

Cant Alastair A. | Zendy; Champion Sue | Zendy; Bhalla Rajiv | Zendy; Pimlott Sally L. | Zendy; Sutherland Andrew | Zendy

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Nickel‐Mediated Radioiodination of Aryl and Heteroaryl Bromides: Rapid Synthesis of Tracers for SPECT Imaging

Author(s) -

Cant Alastair A.,

Champion Sue,

Bhalla Rajiv,

Pimlott Sally L.,

Sutherland Andrew

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201302800

Subject(s) - trifluoroacetic acid , aryl , chemistry , spect imaging , nickel , halogen , single photon emission computed tomography , transformation (genetics) , combinatorial chemistry , radiochemistry , medicinal chemistry , nuclear medicine , organic chemistry , medicine , alkyl , gene , biochemistry

Rapid and efficient radioiodination of aryl and heteroaryl bromides has been achieved using a nickel(0)‐mediated halogen‐exchange reaction. This transformation gives direct access to [ 123 I]‐ and [ 125 I]‐imaging agents for single photon emission computed tomography (SPECT), such as 5‐[ 123 I]‐A85380 (see scheme, Boc= tert ‐butyloxycarbonyl, cod=1,5‐cyclooctadiene, TFA=trifluoroacetic acid).

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