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Synchronous ArF and ArSn Bond Formation through Fluorostannylation of Arynes
Author(s) -
Yoshida Hiroto,
Yoshida Ryuma,
Takaki Ken
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302783
Subject(s) - aryne , intramolecular force , computer science , chemistry , service (business) , bond , combinatorial chemistry , medicinal chemistry , stereochemistry , business , finance , marketing
An aryne insertion into the FSn bond of tributyltin fluoride leads to the synchronous formation of ArF and ArSn bonds to afford diverse 2‐fluoroarylstannanes straightforwardly. The formal total synthesis of flurbiprofen by using a fluorostannylation product is also reported.