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Salicylic Acid and Analogues as diaCEST MRI Contrast Agents with Highly Shifted Exchangeable Proton Frequencies
Author(s) -
Yang Xing,
Song Xiaolei,
Li Yuguo,
Liu Guanshu,
Ray Banerjee Sangeeta,
Pomper Martin G.,
McMahon Michael T.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302764
Subject(s) - salicylic acid , contrast (vision) , content delivery , proton , lanthanide , computer science , saturation (graph theory) , chemistry , nanotechnology , materials science , physics , organic chemistry , nuclear physics , artificial intelligence , mathematics , biochemistry , ion , computer network , combinatorics
More than water : Chemical exchange saturation transfer (CEST) contrast agents have used water bound to lanthanides as a source of highly shifted exchangeable proton frequencies. Compounds with the 2‐hydroxybenzoic acid scaffold were investigated as a source of highly shifted protons for CEST MRI contrasting.