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Controlled Release of Encapsulated Cargo from a DNA Icosahedron using a Chemical Trigger
Author(s) -
Banerjee Anusuya,
Bhatia Dhiraj,
Saminathan Anand,
Chakraborty Saikat,
Kar Shaunak,
Krishnan Yamuna
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302759
Subject(s) - trojan horse , aptamer , trojan , dna , computer science , chemistry , nanotechnology , computational biology , biology , materials science , microbiology and biotechnology , biochemistry , computer security
DNA Trojan horse : A DNA icosahedron (black, see scheme) held together with aptamers (red) was used to encapsulate molecular cargo such as fluorescent dextran (green). In the presence of a molecular trigger (gray hexagons), the aptamers fold back leading to opening of the icosahedron and simultaneous release of the encapsulated cargo.