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Iridium‐Catalyzed Enantioselective Allylic Alkynylation
Author(s) -
Hamilton James Y.,
Sarlah David,
Carreira Erick M.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302731
Subject(s) - allylic rearrangement , enantioselective synthesis , catalysis , iridium , olefin fiber , chemistry , alkynylation , reagent , agonist , combinatorial chemistry , organic chemistry , receptor , biochemistry
No leaving group needed : With an Ir(P,olefin) complex as catalyst, the direct enantioselective allylic alkynylation of secondary allylic alcohols with potassium alkynyltrifluoroborates as alkynylating reagents has been achieved. High levels of enantioselectivity and high yields were achieved with this operationally easy and robust protocol, the use of which was demonstrated in the synthesis of GPR40 receptor agonist AMG 837. cod=1,5‐cyclooctadiene.