Premium
Targeting Intracellular Pathogenic Bacteria with Unnatural Proline‐Rich Peptides: Coupling Antibacterial Activity with Macrophage Penetration
Author(s) -
Kuriakose Jerrin,
HernandezGordillo Victor,
Nepal Manish,
Brezden Anna,
Pozzi Vanessa,
Seleem Mohamed N.,
Chmielewski Jean
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302693
Subject(s) - intracellular , bacteria , lysis , peptide , intracellular parasite , antibacterial peptide , chemistry , bacterial cell structure , microbiology and biotechnology , biochemistry , biology , computational biology , antibacterial activity , genetics
De novo design of unnatural proline‐rich peptides led to a potent antibacterial peptide that targets both Gram‐positive and ‐negative bacteria. The peptide exerts activity without lysing bacterial membranes or causing hemolysis, and is stable to extended trypsin treatment. Facile entry into macrophages was observed, leading to extensive intracellular clearing of pathogenic bacteria.