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Disruption of the Dynamics of Microtubules and Selective Inhibition of Glioblastoma Cells by Nanofibers of Small Hydrophobic Molecules
Author(s) -
Kuang Yi,
Xu Bing
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302658
Subject(s) - nanofiber , microtubule , glioblastoma , small molecule , cytotoxicity , chemistry , cancer cell , biophysics , supramolecular chemistry , microbiology and biotechnology , growth inhibition , cancer , nanotechnology , cell growth , biology , cancer research , biochemistry , molecule , materials science , in vitro , genetics , organic chemistry
Ganging up against the bad guys : Nanofibers of 1 efficiently inhibited the growth of glioblastoma cells but exhibited little acute toxicity toward a neuronal cell line. The selective cytotoxicity probably stems from the Warburg effect of cancer cells and the existence of microtubule‐stabilizing proteins in neurons. Supramolecular nanofibers that can interrupt the self‐organization of proteins may have potential as nanomedicines for the treatment of cancer.