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Synthesis of Neisseria meningitidis Serogroup W135 Capsular Oligosaccharides for Immunogenicity Comparison and Vaccine Development
Author(s) -
Wang ChiaHung,
Li ShiouTing,
Lin TzuLung,
Cheng YangYu,
Sun TsungHsien,
Wang JinTown,
Cheng TingJen R.,
Mong Kwok Kong Tony,
Wong ChiHuey,
Wu ChungYi
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302540
Subject(s) - neisseria meningitidis , immunogenicity , glycan , conjugate vaccine , virology , microbiology and biotechnology , trojan , computational biology , biology , chemistry , antibody , bacteria , computer science , glycoprotein , immunology , biochemistry , genetics , computer security
Sweetening the deal : N. meningitidis serogroup W135 capsular oligosaccharides were synthesized in lengths from disaccharides to decasaccharides. Sera from mice immunized with these oligosaccharide–protein conjugates were examined by a glycan microarray (see picture) and bactericidal assay for antibody specificity and the ability to kill bacteria.