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Use of In Situ Atomic Force Microscopy to Follow Phase Changes at Crystal Surfaces in Real Time
Author(s) -
Thakuria Ranjit,
Eddleston Mark D.,
Chow Ernest H. H.,
Lloyd Gareth O.,
Aldous Barry J.,
Krzyzaniak Joseph F.,
Bond Andrew D.,
Jones William
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302532
Subject(s) - cocrystal , metastability , atomic force microscopy , in situ , crystal (programming language) , nanotechnology , crystallography , phase (matter) , materials science , molecule , chemistry , computer science , organic chemistry , hydrogen bond , programming language
AFM of cocrystals : Atomic force microscopy can be used to observe phase changes at crystal surfaces where the transformation is accompanied by a change in the spacing between layers of molecules (see picture). The conversion of a metastable polymorph of the caffeine–glutaric acid cocrystal into the thermodynamically stable form was analyzed continuously in situ using intermittent‐contact‐mode atomic force microscopy.