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Optical Control of TRPV1 Channels
Author(s) -
Stein Marco,
Breit Andreas,
Fehrentz Timm,
Gudermann Thomas,
Trauner Dirk
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302530
Subject(s) - trpv1 , capsaicin , computer science , channel (broadcasting) , control (management) , azobenzene , transient receptor potential channel , chemistry , information retrieval , world wide web , computer network , artificial intelligence , biochemistry , receptor , organic chemistry , molecule
Controlling pain with light : TRPV1 channels mediate the response to noxious heat and can be activated by capsaicin, the major ingredient of chili pepper. Novel azobenzene photoswitches can be used for the optical control of TRPV1. One of these compounds antagonizes capsaicin in a light‐dependent fashion, demonstrating that a photoswitchable antagonist and an agonist can be applied in concert to modulate ion channel activity.