Premium
Alkyne Phosphonites for Sequential Azide–Azide Couplings
Author(s) -
Vallée M. Robert J.,
Artner Lukas M.,
Dernedde Jens,
Hackenberger Christian P. R.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302462
Subject(s) - azide , cycloaddition , alkyne , computer science , modular design , chemistry , combinatorial chemistry , staudinger reaction , transformation (genetics) , programming language , organic chemistry , catalysis , biochemistry , gene
When Staudinger meets Huisgen! A combination of the copper‐catalyzed variant of the Huisgen azide–alkyne cycloaddition (CuAAC) and the Staudinger reaction, the two most successful chemoselective reactions for the transformation of azides, leads to a chemical method that allows the sequential coupling of two different azido building blocks in high yields. This modular procedure enables a final metal‐free conjugation of functional building blocks to azides.