Alkyne Phosphonites for Sequential Azide–Azide Couplings | Zendy

Vallée M. Robert J. | Zendy; Artner Lukas M. | Zendy; Dernedde Jens | Zendy; Hackenberger Christian P. R. | Zendy

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Alkyne Phosphonites for Sequential Azide–Azide Couplings

Author(s) -

Vallée M. Robert J.,

Artner Lukas M.,

Dernedde Jens,

Hackenberger Christian P. R.

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201302462

Subject(s) - azide , cycloaddition , alkyne , computer science , modular design , chemistry , combinatorial chemistry , staudinger reaction , transformation (genetics) , programming language , organic chemistry , catalysis , biochemistry , gene

When Staudinger meets Huisgen! A combination of the copper‐catalyzed variant of the Huisgen azide–alkyne cycloaddition (CuAAC) and the Staudinger reaction, the two most successful chemoselective reactions for the transformation of azides, leads to a chemical method that allows the sequential coupling of two different azido building blocks in high yields. This modular procedure enables a final metal‐free conjugation of functional building blocks to azides.

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