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LovG: The Thioesterase Required for Dihydromonacolin L Release and Lovastatin Nonaketide Synthase Turnover in Lovastatin Biosynthesis
Author(s) -
Xu Wei,
Chooi YitHeng,
Choi Jin W.,
Li Shuang,
Vederas John C.,
Da Silva Nancy A.,
Tang Yi
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302406
Subject(s) - lovastatin , thioesterase , biosynthesis , atp synthase , chemistry , biochemistry , hydrolysis , enzyme , cholesterol
No Lov lost : The cryptic thioesterase LovG was found to be responsible for product release from the lovastatin nonaketide synthase (LNKS or LovB; see scheme). LovG also helped improve the turnover of LovB through hydrolysis of incorrectly made intermediates, freeing LovB for another round of catalysis.