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Back Cover: A Chemical Probe for Lysine Malonylation (Angew. Chem. Int. Ed. 18/2013)
Author(s) -
Bao Xiucong,
Zhao Qian,
Yang Tangpo,
Fung Yi Man Eva,
Li Xiang David
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302391
Subject(s) - bioorthogonal chemistry , lysine , click chemistry , chemistry , posttranslational modification , profiling (computer programming) , biochemistry , cover (algebra) , computational biology , biophysics , microbiology and biotechnology , combinatorial chemistry , computer science , biology , enzyme , amino acid , engineering , mechanical engineering , operating system
Lysine malonylation is a newly identified posttranslational protein modification, whose cellular functions remain largely unknown. In their Communication on page 4883 ff., Y. M. E. Fung, X. D. Li, and co‐workers develop the first chemical reporter, MalAM‐yne, to detect malonylation of proteins in living cells. The subsequent bioorthogonal conjugation enables the visualization of the dynamics of malonylation and rapid profiling of malonylated proteins.