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Opsin, a Structural Model for Olfactory Receptors?
Author(s) -
Park Jung Hee,
Morizumi Takefumi,
Li Yafang,
Hong Joo Eun,
Pai Emil F.,
Hofmann Klaus Peter,
Choe HuiWoog,
Ernst Oliver P.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302374
Subject(s) - g protein coupled receptor , opsin , receptor , computational biology , computer science , olfactory receptor , rhodopsin , olfactory system , neuroscience , world wide web , cognitive science , information retrieval , biology , psychology , genetics , biochemistry , retinal
Receptor–ligand interaction : Olfactory receptors (ORs) are G‐protein‐coupled receptors (GPCRs), which detect signaling molecules such as hormones and odorants. The structure of opsin, the GPCR employed in vision, with a detergent molecule bound deep in its orthosteric ligand‐binding pocket provides a template for OR homology modeling, thus enabling investigation of the structural basis of the mechanism of odorant–receptor recognition.