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Two‐Step Protein Self‐Assembly in the Extracellular Matrix
Author(s) -
Park Won Min,
Champion Julie A.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302331
Subject(s) - coacervate , extracellular matrix , mcherry , computer science , nanotechnology , matrix (chemical analysis) , chemistry , computational biology , biophysics , materials science , biochemistry , biology , green fluorescent protein , gene , chromatography
Carrier‐free protein delivery : Protein self‐assembly can be conducted in the extracellular matrix (ECM) where engineered protein components (Z R ‐ELP) form particles that become entrapped, bind a model protein (mCherry‐Z E ), and dissociate. Spontaneous diffusion–coacervation and high‐affinity binding of proteins mediate in situ formation of the self‐assembled particles that shrink and release the model protein in the ECM (see scheme).