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Total Synthesis of the Ribosomally Synthesized Linear Azole‐Containing Peptide Plantazolicin A from Bacillus amyloliquefaciens
Author(s) -
Banala Srinivas,
Ensle Paul,
Süssmuth Roderich D.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302266
Subject(s) - azole , bacillus amyloliquefaciens , dipeptide , peptide , combinatorial chemistry , chemistry , stereochemistry , organic chemistry , biochemistry , biology , microbiology and biotechnology , antifungal , fermentation
A cyclodehydration reaction has been used to synthesize the linear azole‐containing peptide plantazolicin A. The target compound was synthesized from two heterocyclic fragments derived from dipeptide building blocks. The acid‐labile oxazolines and thiazoles necessitate the use of a Teoc/TMSE‐based protection‐group strategy, which allows structure modification of plantazolicin.