Premium
Tuning the Intracellular Bacterial Targeting of Peptidic Vectors
Author(s) -
Lei Eric K.,
Pereira Mark P.,
Kelley Shana O.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302265
Subject(s) - intracellular , peptide , computational biology , drug delivery , vector (molecular biology) , toolbox , computer science , chemistry , biology , biochemistry , gene , recombinant dna , organic chemistry , programming language
Engineered vectors for intracellular targeting : Engineered peptides were used as a methotrexate delivery vector against intracellular L. monocytogenes. A peptide library was developed to determine the chemical properties required for specific drug delivery to bacteria while maintaining mitochondrial localization as a drug reservoir. Mtx–peptide conjugates were found to have higher antimicrobial activity and lower human cell toxicity.