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The Role of Water and Sodium Ions in the Activation of the μ‐Opioid Receptor
Author(s) -
Yuan Shuguang,
Vogel Horst,
Filipek Slawomir
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302244
Subject(s) - sodium , chemistry , opioid , opioid receptor , ion , receptor , biochemistry , organic chemistry
Dual effect of sodium ions : The activation of G‐protein‐coupled receptors depends on the presence of water molecules inside the receptor and also on allosteric interactions. The binding of sodium ions to the allosteric site of the μ opioid receptor was studied by microsecond molecular dynamics simulations and their seemingly contradictory roles in preventing ligand binding and facilitating receptor activation were explained.