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Photoactivatable Chemokines – Controlling Protein Activity by Light
Author(s) -
Baumann Lars,
BeckSickinger Annette G.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302242
Subject(s) - chemotaxis , depsipeptide , chemokine , chemistry , ligation , microbiology and biotechnology , biophysics , biochemistry , biology , receptor
Activation by light : Caged depsipeptides are incorporated as photoresponsive elements into the backbone of the protein SDF‐1α by using expressed protein ligation. The disturbed secondary structure is restored after UV treatment by an O→N acyl rearrangement, and the chemotactic potential of the protein is regained. Nvoc=6‐nitroveratryloxycarbonyl.