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Enantiopure Water‐Soluble [Fe 4 L 6 ] Cages: Host–Guest Chemistry and Catalytic Activity
Author(s) -
Bolliger Jeanne L.,
Belenguer Ana M.,
Nitschke Jonathan R.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302136
Subject(s) - enantiopure drug , enantiomer , chemistry , catalysis , dichlorvos , hydrolysis , organophosphate , host (biology) , molecule , stereochemistry , combinatorial chemistry , organic chemistry , pesticide , enantioselective synthesis , ecology , agronomy , biology
Inside information : The new enantiopure cage molecule ΔΔΔΔ‐Fe 4 L 6 (and its enantiomer, ΛΛΛΛ‐Fe 4 L 6 ) was prepared by subcomponent self‐assembly. It binds a range of organic guests ( A , see scheme) in its cavity and distinguishes between the enantiomers of a chiral organic guest. Host ΔΔΔΔ‐Fe 4 L 6 is also a catalyst for the hydrolysis (giving B and C ) of the neurotoxic organophosphate dichlorvos.