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Cover Picture: Chiral Magnesium(II) Binaphtholates as Cooperative Brønsted/Lewis Acid–Base Catalysts for the Highly Enantioselective Addition of Phosphorus Nucleophiles to α,β‐Unsaturated Esters and Ketones (Angew. Chem. Int. Ed. 17/2013)
Author(s) -
Hatano Manabu,
Horibe Takahiro,
Ishihara Kazuaki
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302124
Subject(s) - enantioselective synthesis , chemistry , catalysis , lewis acids and bases , phosphine , nucleophile , chelation , supramolecular chemistry , medicinal chemistry , organic chemistry , molecule
Supramolecular catalysts relying on cooperation between Mg ions and a chelating complex (represented by carp in the picture) were developed by K. Ishihara and co‐workers in their Communication on page 4549 ff. The enantioselective 1,4‐hydrophosphinylation of α,β‐unsaturated esters with diaryl phosphine oxides and 1,2‐hydrophosphonylation of α,β‐unsaturated ketones with dialkyl phosphites was achieved using chiral 3:2 complexes of ( R )‐(H 8 ‐)BINOLate/Mg II ions.