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Design and Synthesis of Cyclic ADP‐4‐Thioribose as a Stable Equivalent of Cyclic ADP‐Ribose, a Calcium Ion‐Mobilizing Second Messenger
Author(s) -
Tsuzuki Takayoshi,
Sakaguchi Natsumi,
Kudoh Takashi,
Takano Satoshi,
Uehara Masato,
Murayama Takashi,
Sakurai Takashi,
Hashii Minako,
Higashida Haruhiro,
Weber Karin,
Guse Andreas H.,
Kameda Tomoshi,
Hirokawa Takatsugu,
Kumaki Yasuhiro,
Potter Barry V. L.,
Fukuda Hayato,
Arisawa Mitsuhiro,
Shuto Satoshi
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302098
Subject(s) - cyclic adp ribose , second messenger system , calcium , chemistry , ribose , ion , biophysics , stereochemistry , signal transduction , biochemistry , enzyme , biology , microbiology and biotechnology , organic chemistry , cd38 , stem cell , cd34
Oh, what a difference an S makes : A thioribose analogue (cADPtR, see scheme) of cyclic ADP‐ribose (cADPR) was synthesized that is stable and has structural and electrostatic features similar to those of cADPR. cADPtR is the first stable equivalent of cADPR that is as active as cADPR in various cellular systems, making it useful for investigating Ca 2+ ion‐release signaling pathways.