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Spatially Controlled Surface Immobilization of Nonmodified Peptides
Author(s) -
Pauloehrl Thomas,
Welle Alexander,
Bruns Michael,
Linkert Katharina,
Börner Hans G.,
Bastmeyer Martin,
Delaittre Guillaume,
BarnerKowollik Christopher
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201302040
Subject(s) - chemistry , peptide , secondary ion mass spectrometry , derivative (finance) , mass spectrometry , amino acid , stereochemistry , combinatorial chemistry , photochemistry , organic chemistry , polymer chemistry , chromatography , biochemistry , financial economics , economics
A phencyclone derivative is used to achieve light‐controlled immobilization of peptides possessing only natural amino acids. The photoactive precursor (blue in picture) is formed in a Diels–Alder reaction and can undergo light‐triggered ring‐opening reactions with amines. Successful surface patterning with a genuine c(RGDfK) peptide (green) is evidenced by imaging time‐of‐flight secondary‐ion mass spectrometry (ToF‐SIMS).